In this paper we report about the use of computer generated affect to control body and mind of cognitively modeled virtual characters. We use the computational model of affect ALMA that is able to simulate three different affect types in real-time. The computation of affect is based on a novel approach of an appraisal language. Both the use of elements of the appraisal language and the simulation of different affect types has been evaluated. Affect is used to control facial expressions, facial complexions, affective animations, posture, and idle behavior on the body layer and the selection of dialogue strategies on the mind layer. To enable a fine-grained control of these aspects a Player Markup Language (PML) has been developed. The PML is player-independent and allows a sophisticated control of character actions coordinated by high-level temporal constraints. An Action Encoder module maps the output of ALMA to PML actions using affect display rules. These actions drive the real-time rendering of affect, gesture and speech parameters of virtual characters, which we call Virtual Humans.